Computational Approaches To Anti-Toxin Therapies And Biomarker Identification
نویسندگان
چکیده
Statistical Analysis: We utilized four publically available case/control genome wide association studies (GWAS) from dbGAP (access request # 1961) across multiple cancer types (including breast, melanoma. lung and prostate cancers)(14, 523, 524, 526-528) to determine if SNPs or haplotypes constructed from SNPs in our genes of interest are associated with a disease phenotype. Additionally, we determined if any synergistic results across multiple databases exist that may imply a common cancer genesis. Multiple genetic modes of inheritance were examined: additive, dominant, recessive and genotypic in a covariate-adjusted logistic regression analysis associating each SNP with the disease phenotype. The maximum
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